Nattokinase Clinical Studies
Sumi discovered Nattokinase in 1980 while conducting research at
Chicago University. Dr Sumi was testing hundreds of natural foods for
their thrombolytic potential. After dropping Nattō onto artificial
thrombus and allowing it to stand at body temperature, he observed
that the thrombus gradually dissolved and within 18 hours was
Sumi next began clinical trials with humans and animals. In the first
study, 12 volunteers were given 200 grams of Nattō daily. The
fibrinolytic activity of their blood was then measured in two ways.
The euglobulin clot lysis test involved taking a blood sample and
stimulating an artificial thrombus (clot) within the sample. The time
taken to completely dissolve the clot was then measured. The
Nattokinase group managed to half the dissolve time of the control
second test involved the addition of blood to a plate with a special
polymerized fibrinogen. Rate of dissolution was measured over a four
hour period. The control group showed no dissolution whereas the
Nattokinase group averaged a dissolution of 15 sq mm.
a further test, Dr Sumi had volunteers take Nattokinase for 8 days. A
third test was then administered to measure tissue plasminogen
activator (TPA) blood levels. The Nattokinase takers had increased
their TPA activity. TPA increases plasmin, so the study showed that,
in addition to dissolving fibrinogen, Nattokinase can augment the
body’s own fibrinolytic activity.
Sumi also conducted a clinical trial involving dogs. One group of
dogs was fed Nattokinase while another group was given a placebo. A
thrombus was then created in a leg vein of each dog. Within 5 hours
the Nattokinase fed dogs leg vein circulation was completely
obstruction free. The placebo dogs still had the thrombus induced
blockage 18 hours later (Sumi H, Hamada H, Tsushima H, Mihara H,
Muraki H. A novel fibrinolytic enzyme (Nattokinase) in the vegetable
cheese Nattō; a typical and popular soybean food in the Japanese
diet. Experientia 1987, Oct 15;43(10):1110-1.).
1995, Researchers from
Biotechnology Research Laboratories and JCR Pharmaceuticals Co. of
Kobe, Japan tested the
effectiveness of Nattokinase to reduce thrombus in the carotid artery
of rats. Several rats had a thrombus artificially inserted into the
carotid artery, which feeds the brain. Three enzymes - Nattokinase,
plasmin and elastase – were then tested on the rats. Those given
elastase showed no re-opening of the blocked artery. The plasmin fed
rats showed a 16 % restoration of circulation after an hour. However,
the Nattokinase fed rats displayed a 62 % restoration of circulation
within that time frame. This led researchers to the conclusion that
“the results indicate that the thrombolytic activity of Nattokinase
is stronger than that of plasmin or elastase in vivo” (Sumi H.
Healthy Microbe "Bacillus Nattō". Japan Bio Science
Laboratory Co. Ltd).
from JCR Pharmaceuticals, Oklahoma State University and Miyazaki
Medical College conducted a further study in which 12 volunteers were
given 200 mg of Nattokinase and then tracked their fibrinolytic
activity through a series of blood plasma tests. The subjects
exhibited a heightened ability to dissolve blood clots for 2 to 8
hours (Prevent Heart Attack and Stroke with Potent Enzyme that
Dissolves Deadly Blood Clots in Hours. Health Sciences Institute,
2003 the Long – Flite randomized control trial conducted by Cesarone, et al, Nattokinase or a placebo were given to volunteers
prior to a 7-8 hour flight. 7 of the 92 people in the placebo group
developed a clot. None of the 94 people in the Nattokinase group
developed a clot (Cesarone MR et al.: Prevention of venous thrombosis
in long-haul flights with Flite Tabs: The LONG-FLITE randomized,
controlled trial. Angiology 2003;54:T1-T9).
1995, researchers from Miyazaki Medical College and Kurashiki
University of Science and Arts in Japan studied the effects of
Nattokinase on blood pressure in both animal and human subjects. In
the animal trial male wister rats were administered a single dose of
400-450 grams of Nattokinase. On average the systolic blood pressure
(SBP) of the rats dropped by 12.7% in two hours.
human trial consisted of oral administration of 30 grams of
lyophilized extract to volunteers with high blood pressure. The
subjects averaged a 10.9 % drop in SBP and a 9.7 % drop in diastolic
blood pressure (DBP) (Maruyama M, Sumi H. Effect of Nattō Diet on
Blood Pressure. JTTAS, 1995.).